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Phenotypes Associated with This Genotype
Genotype
MGI:4366790
Allelic
Composition		 Dclre1ctm2.1Jpdv/Dclre1ctm2.2Jpdv
Tg(Cr2-cre)3Cgn/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclre1ctm2.1Jpdv mutation (1 available); any Dclre1c mutation (30 available)
Dclre1ctm2.2Jpdv mutation (0 available); any Dclre1c mutation (30 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:153841 )
N
• mice exhibit normal B cell development and Ig titers
abnormal class switch recombination ( J:153841 )
• class switching to IgG3 is decreased 23% compared to in wild-type mice
• in vivo Ig switching to IgA on KLH immunization is reduced 52% compared to in similarly treated wild-type mice
• class switch recombination junctions are altered compared to in wild-type mice

hematopoietic system
abnormal class switch recombination ( J:153841 )
• class switching to IgG3 is decreased 23% compared to in wild-type mice
• in vivo Ig switching to IgA on KLH immunization is reduced 52% compared to in similarly treated wild-type mice
• class switch recombination junctions are altered compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory