Phenotypes for Clock Lep MGI:4366719 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Clock^m1Jt/Clock^m1Jt Lep^ob/Lep^ob
Genetic Background	involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clock^m1Jt mutation (3 available); any Clock mutation (105 available)
Lep^ob mutation (5 available); any Lep mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:135847 )

• compared to in Lep^ob homozygotes

increased circulating glucose level ( J:135847 )

• compared to in wild-type and Clock^m1Jt homozygotes

decreased circulating insulin level ( J:135847 )

• compared to in Lep^ob homozygotes

increased circulating insulin level ( J:135847 )

• compared to in wild-type and Clock^m1Jt homozygotes

increased circulating cholesterol level ( J:135847 )

• compared to in wild-type or single homozygotes

increased circulating free fatty acids level ( J:135847 )

• compared to in wild-type and Clock^m1Jt homozygotes

increased circulating triglyceride level ( J:135847 )

• compared to in wild-type or single homozygotes

adipose tissue

increased fat cell size ( J:135847 )

growth/size/body

increased body weight ( J:135847 )

• compared to in wild-type or single homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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