Phenotypes for Hr Ptgs1 MGI:4366349 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hr^hr/Hr^hr Ptgs1^tm1Unc/Ptgs1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SKH1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hr^hr mutation (18 available); any Hr mutation (89 available)
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:121635 )

N	• UV-exposed mice exhibit normal induction of tumors

homeostasis/metabolism

decreased prostaglandin level ( J:121635 )

• 50% in the epidermis

cellular

increased cell proliferation ( J:121635 )

• skin from UV-treated mice exhibits 20% less basal cell proliferation than in skin from similarly treated wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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