Phenotypes Associated with This Genotype

Genotype
MGI:4366348

• Allelic Composition: Hr^hr/Hr^hr; Ptgs2^tm1Unc/Ptgs2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SKH1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by UV induction ( J:121635 )

• after 14 weeks of UV treatment, mice fail to develop tumors unlike similarly treated SKH mice and do not develop tumors until 24 weeks of treatment

• UV-treated mice exhibit a 65% reduction in tumor number and decreased tumor incidence compared with similarly treated wild-type mice

homeostasis/metabolism

decreased prostaglandin level ( J:121635 )

• 50% in the epidermis

decreased incidence of tumors by UV induction ( J:121635 )

• after 14 weeks of UV treatment, mice fail to develop tumors unlike similarly treated SKH mice and do not develop tumors until 24 weeks of treatment

• UV-treated mice exhibit a 65% reduction in tumor number and decreased tumor incidence compared with similarly treated wild-type mice

cellular

increased cell proliferation ( J:121635 )

• skin from UV-treated mice exhibits 50% less basal cell proliferation than in skin from similarly treated wild-type mice