Phenotypes for Apc Ptgs1 MGI:4366248 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Apc^Min/Apc⁺ Ptgs1^tm1Unc/Ptgs1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (154 available)
Ptgs1^tm1Unc mutation (0 available); any Ptgs1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:64401 )

• mice survive 10 months unlike Apc^Min heterozygotes that die after 7 to 8 months

neoplasm

decreased tumor incidence ( J:64401 )

• mice form 43% fewer tumors than in Apc^Min heterozygotes

digestive/alimentary system

intestine polyps ( J:64401 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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