Phenotypes Associated with This Genotype

Genotype
MGI:4366029

• Allelic Composition: Pkd1^tm3.2Bol/Pkd1^tm3.2Bol
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:153606 )

• 90% of mice survive to E15.5, 60% of mice survive to E16.5, and none survive to E17.5

nervous system

abnormal brain vasculature morphology ( J:153606 )

• vessels are dilated at E16.5

hydrocephaly ( J:153606 )

• mild at E16.5

dilated lateral ventricle ( J:153606 )

• mild without aqueduct stenosis

dilated third ventricle ( J:153606 )

• without aqueduct stenosis

renal/urinary system

kidney cyst ( J:153606 )

• at E15.5, mice develop tubular and glomerular cysts unlike wild-type mice

homeostasis/metabolism

edema ( J:153606 )

• beginning at E14.5 and worsening at E15.5

cardiovascular system

abnormal brain vasculature morphology ( J:153606 )

• vessels are dilated at E16.5

hemorrhage ( J:153606 )

• beginning at E14.5 and worsening at E15.5

growth/size/body

kidney cyst ( J:153606 )

• at E15.5, mice develop tubular and glomerular cysts unlike wild-type mice