Phenotypes Associated with This Genotype

Genotype
MGI:4365971

hm1

• Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts
• Genetic Background: B6.129S7-Ifng^tm1Ts

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:77491 )

• in a few mice

mortality/aging

increased susceptibility to parasitic infection induced morbidity/mortality ( J:18801 , J:110826 )

• sudden death occurs 5 to 7 weeks after infection with Leishmania major (J:18801)

• die earlier after inoculation with Toxoplasma gondii (strain ME49) compared to wild-type controls (J:110826)

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:112048 )

• higher mortality is seen following infection with JHMV compared to wild-type controls

premature death ( J:77491 )

• Background Sensitivity: in mice on a C57BL/6 background compared to mice on a BALB/c background

neoplasm

increased lymphoma incidence ( J:77491 )

• Background Sensitivity: 50% of mice on a congenic C57BL/5 background develop disseminated lymphomas compared to 0% of mice on a congenic BALB/c background

• most lymphomas are diffuse large cell lymphomas

increased T cell derived lymphoma incidence ( J:77491 )

• in a few mice

increased sarcoma incidence ( J:77491 )

• in a few mice

decreased tumor latency ( J:77491 )

• Background Sensitivity: in mice on a C57BL/6 background compared to mice on a BALB/c background

immune system

increased CD8-positive, alpha-beta T cell number ( J:112048 )

• increase in the number of CD8+ cells in the white matter tracts of JHMV infected mice compared to similarly infected wild-type controls at 7 and 14 days post infection

abnormal B cell physiology ( J:112084 )

• immature B cells fail to be excluded from the lymph nodes

abnormal immunoglobulin level ( J:18801 )

increased IgE level ( J:18801 )

• after infection with Leishmania major

increased IgG1 level ( J:18801 , J:112048 )

• after infection with Leishmania major (J:18801)

• 5-fold increase in the serum levels of JHMV specific IgG1 at 14 days post infection compared to infected wild-type controls (J:112048)

decreased IgG2a level ( J:18801 )

• after infection with Leishmania major

decreased IgG3 level ( J:18801 )

• after infection with Leishmania major

abnormal lymph node cell ratio ( J:112084 )

• significant increase in the numbers of immature B cells in the lymph nodes

abnormal cytokine secretion ( J:18801 , J:110826 )

• after infection with Leishmania major the number of lymphocytes producing IL4 increases unlike in control mice where the number of lymphocytes producing IFNG increases (J:18801)

• following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice (J:110826)

increased interleukin-10 secretion ( J:112048 )

• cervical lymph node cells from JHMV infected mice (7 days post infection) secrete more IL10 in response to JHMV antigen compared to cells from similarly infected wild-type mice

increased interleukin-2 secretion ( J:112048 )

• cervical lymph node cells from JHMV infected mice secrete more IL2 in response to JHMV antigen compared to cells from similarly infected wild-type mice

increased interleukin-5 secretion ( J:112048 )

• cervical lymph node cells from JHMV infected mice (7 days post infection) secrete more IL5 in response to JHMV antigen compared to cells from similarly infected wild-type mice

abnormal response to infection ( J:18801 , J:110826 )

• after infection with Leishmania major mice display minimal Th1 type responses and increased Th2 type responses (J:18801)

• after infection with Leishmania major levels of IgG1 and IgE are increased while levels of IgG2a and IgG3 remain low (J:18801)

• following infection with T. gondii (irradiate RH strain) splenocytes show enhanced Th2 cytokine production compared to similar cultures from wild-type mice (J:110826)

increased susceptibility to parasitic infection ( J:18801 )

• develop progressive infection characterized by large lesions at the site of inoculation and sudden death 5 to 7 weeks after infection with Leishmania major

• numbers of parasites present in the footpads are substantially increased compared to wild-type and heterozygous controls

increased susceptibility to parasitic infection induced morbidity/mortality ( J:18801 , J:110826 )

• sudden death occurs 5 to 7 weeks after infection with Leishmania major (J:18801)

• die earlier after inoculation with Toxoplasma gondii (strain ME49) compared to wild-type controls (J:110826)

increased susceptibility to Coronaviridae infection ( J:112048 )

• following infection with the JHM strain of mouse hepatitis virus (JHMV) mice display a slower clinical recovery and higher viral titers in the central nervous system compared to wild-type controls

• however, no differences are found in JHMV specific cytotoxic T lymphocyte activity

• at 14 days post infection with JHMV a 10 fold increase in the number of viral antigen positive cells is detected in the brain with most of the infected cells being oligodendrocytes

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:112048 )

• higher mortality is seen following infection with JHMV compared to wild-type controls

abnormal response to transplant ( J:42090 )

• after immunosuppressive treatment (anti-CD4 and anti-CD8 mAbs) allografts (BALB/c, H2-Ab1^bm12 continue to display myocardial rejection at week 12 but do not display graft arterial disease, in contrast wild-type mice at week 12 display low levels of rejection but develop coronary arteriopathy

hematopoietic system

increased CD8-positive, alpha-beta T cell number ( J:112048 )

• increase in the number of CD8+ cells in the white matter tracts of JHMV infected mice compared to similarly infected wild-type controls at 7 and 14 days post infection

abnormal B cell physiology ( J:112084 )

• immature B cells fail to be excluded from the lymph nodes

abnormal immunoglobulin level ( J:18801 )

increased IgE level ( J:18801 )

• after infection with Leishmania major

increased IgG1 level ( J:18801 , J:112048 )

• after infection with Leishmania major (J:18801)

• 5-fold increase in the serum levels of JHMV specific IgG1 at 14 days post infection compared to infected wild-type controls (J:112048)

decreased IgG2a level ( J:18801 )

• after infection with Leishmania major

decreased IgG3 level ( J:18801 )

• after infection with Leishmania major