Phenotypes Associated with This Genotype

Genotype
MGI:4365608

• Allelic Composition: Trp73^tm1(cre)Agof/Trp73^tm1(cre)Agof
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased neuron apoptosis ( J:153209 )

• at E13.5, apoptotic Cajal-Retzius cells are detected in the cortical marginal zone and cortical hem; in the trigeminal ganglion, apoptosis is drastically increased compared to wild-type controls

abnormal vomeronasal organ morphology ( J:153209 )

• in adults, vomeronasal organ (VNO) neurons and axons are significantly reduced in numbers

decreased gonadotropin-releasing hormone neuron number ( J:153209 )

• number of GnRH-positive neurons in preoptic area (generated initially in VNO) is dramatically reduced at P0

abnormal forebrain development ( J:153209 )

• from E12.5 onward, number of Cajal-Retzius cells in marginal zone, thalamic eminence, or choroid plexuses labeling for the deleted Trp73 isoform DeltaNp73 progressively decreases compared to controls, becoming significant after birth; at P0, Reelin-positive cells are reduced by 50%

abnormal cortical marginal zone morphology ( J:153209 )

decreased Cajal-Retzius cell number ( J:153209 )

abnormal choroid plexus morphology ( J:153209 )

• choroid plexus is reduced in size at P0

abnormal trigeminal ganglion morphology ( J:153209 )

endocrine/exocrine glands

decreased gonadotropin-releasing hormone neuron number ( J:153209 )

• number of GnRH-positive neurons in preoptic area (generated initially in VNO) is dramatically reduced at P0

reproductive system

reduced fertility ( J:153209 )

• both males and females exhibit impaired fertility; this is particularly evident in females which generate only 2 or three litters

respiratory system

abnormal vomeronasal organ morphology ( J:153209 )

• in adults, vomeronasal organ (VNO) neurons and axons are significantly reduced in numbers

craniofacial

abnormal vomeronasal organ morphology ( J:153209 )

• in adults, vomeronasal organ (VNO) neurons and axons are significantly reduced in numbers

cellular

increased neuron apoptosis ( J:153209 )

• at E13.5, apoptotic Cajal-Retzius cells are detected in the cortical marginal zone and cortical hem; in the trigeminal ganglion, apoptosis is drastically increased compared to wild-type controls

growth/size/body

abnormal vomeronasal organ morphology ( J:153209 )

• in adults, vomeronasal organ (VNO) neurons and axons are significantly reduced in numbers