Phenotypes Associated with This Genotype

Genotype
MGI:4365591

• Allelic Composition: Fasl^gld/Fasl^gld
• Genetic Background: involves: C3H/HeJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:153501 )

immune system

immune system phenotype ( J:153501 )

N • mice mount a normal immune response to influenza

enlarged spleen ( J:153501 )

• by 14 weeks

increased T cell number ( J:153501 )

• TCRalpha/beta+CD4-CD8-B220+ T cells

increased IgE level ( J:153501 )

increased IgG level ( J:153501 )

increased IgG1 level ( J:153501 )

increased IgG2a level ( J:153501 )

increased IgG2b level ( J:153501 )

increased circulating tumor necrosis factor level ( J:153501 )

enlarged lymph nodes ( J:153501 )

• by 14 weeks

increased susceptibility to systemic lupus erythematosus ( J:153501 )

• by 57 weeks, 15% of mice develop fatal SLE-like autoimmune kidney disease unlike wild-type mice

increased anti-nuclear antigen antibody level ( J:153501 )

• in some mice

dermatitis ( J:153501 )

• in 10% of mice and later than in Fasl^tm1.1Ast homozygotes

neoplasm

increased histiocytic sarcoma incidence ( J:153501 )

• rare

homeostasis/metabolism

increased circulating tumor necrosis factor level ( J:153501 )

decreased susceptibility to injury ( J:76811 )

• following pancreatic duct ligation, mice exhibit virtually no acinar cell loss or ductal metaplasia compared with similarly treated wild-type mice

• following pancreatic duct ligation, mice exhibit less acinar cell apoptosis than similarly treated wild-type mice

• however, areas of inflammation and fibrosis are sometimes observed following pancreatic duct ligation

hematopoietic system

enlarged spleen ( J:153501 )

• by 14 weeks

increased T cell number ( J:153501 )

• TCRalpha/beta+CD4-CD8-B220+ T cells

increased IgE level ( J:153501 )

increased IgG level ( J:153501 )

increased IgG1 level ( J:153501 )

increased IgG2a level ( J:153501 )

increased IgG2b level ( J:153501 )

integument

dermatitis ( J:153501 )

• in 10% of mice and later than in Fasl^tm1.1Ast homozygotes

growth/size/body

enlarged spleen ( J:153501 )

• by 14 weeks