Phenotypes for Egr2 Ptpn11 MGI:4365548 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Egr2^tm2(cre)Pch/Egr2⁺ Ptpn11^tm1.1Wbm/Ptpn11^tm1.1Wbm
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr2^tm2(cre)Pch mutation (2 available); any Egr2 mutation (31 available)
Ptpn11^tm1.1Wbm mutation (1 available); any Ptpn11 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased motor neuron number ( J:153219 )

• in the ventral but not dorsal roots

abnormal myelination ( J:153219 , J:207470 )

• peripheral nerves are hypomyelinated with thinner myelin in axons with larger axon diameter (J:153219)

decreased nerve conduction velocity ( J:153219 )

• in the saphenous nerve

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23