Phenotypes for H2az2 Ptpn11 MGI:4365544 MGI Mouse

embryonic lethality during organogenesis, incomplete penetrance ( J:153219 )

• most mice die around E13.5

• at E11.5, cutaneous, intercostal, and limb sensory neuron projections exhibit reduced axonal arborization compared to in wild-type mice

• however, incubation with wild-type Schwann cells restores axon outgrowth

abnormal axon fasciculation ( J:153219 )

• at E11.5, cutaneous, intercostal, and limb sensory neuron projections exhibit defasciculation unlike in wild-type mice

decreased enteric neural crest cell number ( J:153219 )

• Ret+ enteric neural crest cells are reduced compared to in wild-type mice

decreased Schwann cell precursor number ( J:153219 )

• at E11.5, BFABP+ Schwann cell precursors are reduced compared to in wild-type mice

absent Schwann cell precursors ( J:153219 )

• at E12.5, Sox10+ Schwann cell precursors are not detected in peripheral nerves unlike in wild-type mice

decreased Schwann cell number ( J:153219 )

• at E13.5, Schwann cell nuclei in peripheral nerves are virtually absent unlike in wild-type mice

abnormal sensory neuron innervation pattern ( J:153219 )

• at E11.5, cutaneous, intercostal, and limb sensory neuron projections exhibit defasciculation and reduced axonal arborization compared to in wild-type mice

decreased sensory neuron number ( J:153219 )

• at E12.5, lumbar dorsal root ganglia sensory neurons exhibit increased cell death compared to in wild-type mice

• numbers of sensory neurons in the dorsal root ganglia are strongly reduced compared to in wild-type mice

abnormal craniofacial morphology ( J:153219 )

abnormal melanocyte morphology ( J:153219 )

• melanocytes are reduced in number compared to in wild-type mice