Phenotypes Associated with This Genotype

Genotype
MGI:4362033

• Allelic Composition: Per1^tm1Brd/Per1^tm1Brd; Per2^tm1Brd/Per2^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased osteoblast proliferation ( J:115188 )

• in culture osteoblasts grow faster

• the mitotic index of osteoblasts is increased and the cell cycle length is decreased

increased osteoblast cell number ( J:115188 )

• basal osteoblast numbers are increased

• long term treatment with leptin increases rather than decreases osteoblast numbers

increased bone mass ( J:115188 )

• beginning at 6 weeks of age bone mass is increased in the long bones and vertebrae

• increase in bone mass worsens with age

• long term treatment with leptin increases rather than decreases bone mass

abnormal skeleton development ( J:115188 )

• increase in all bone formation parameters

cellular

increased osteoblast proliferation ( J:115188 )

• in culture osteoblasts grow faster

• the mitotic index of osteoblasts is increased and the cell cycle length is decreased

abnormal fibroblast physiology ( J:193286 )

• loss of circadian regulation of cell division in primary fibroblasts

hematopoietic system

abnormal bone marrow cell morphology/development ( J:115188 )

• increase in the numbers of stromal and osteoblast progenitor cells

homeostasis/metabolism

increased circulating leptin level ( J:115188 )

• increase in total and bound levels of leptin

• however, levels of free leptin (active form) are similar to controls

abnormal urine catecholamine level ( J:115188 )

• norepinephrine excretion is increased at Zeitgeber time (ZT) 22

impaired wound healing ( J:193286 )

• following wounding develop a thick layer of immature granulation tissue that was dominated by an excess of fibroblasts as well as polymorphonuclear cells

renal/urinary system

abnormal urine catecholamine level ( J:115188 )

• norepinephrine excretion is increased at Zeitgeber time (ZT) 22