About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4361930
Allelic
Composition		 Shc1tm6Paw/Shc1tm6Paw
Tg(MMTV-PyVT)634Mul/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm6Paw mutation (0 available); any Shc1 mutation (66 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:133325 )
• tumor nodules are present throughout the entire mammary gland
• lesions eventually progress to carcinoma
• tumors are highly apoptotic compared to tumors from Tg(MMTV-PyVT)634Mul single mutants
• tumor angiogenesis is decreased relative to tumors from Tg(MMTV-PyVT)634Mul single mutants
decreased metastatic potential ( J:133325 )
• number of mice displaying lung metastases is decreased about 3-fold compared to Tg(MMTV-PyVT)634Mul single mutants (30 vs 91 mice)
increased tumor latency ( J:133325 )
• mammary tumor latency is strongly increased compared to Tg(MMTV-PyVT)634Mul single mutants (132 days vs 66 days)

endocrine/exocrine glands
abnormal mammary gland morphology ( J:133325 )
• entire gland is hyperplastic
• mammary glands are composed of single layer of epithelial cells surrounding a dilated lumen
increased mammary gland tumor incidence ( J:133325 )
• tumor nodules are present throughout the entire mammary gland
• lesions eventually progress to carcinoma
• tumors are highly apoptotic compared to tumors from Tg(MMTV-PyVT)634Mul single mutants
• tumor angiogenesis is decreased relative to tumors from Tg(MMTV-PyVT)634Mul single mutants

integument
abnormal mammary gland morphology ( J:133325 )
• entire gland is hyperplastic
• mammary glands are composed of single layer of epithelial cells surrounding a dilated lumen
increased mammary gland tumor incidence ( J:133325 )
• tumor nodules are present throughout the entire mammary gland
• lesions eventually progress to carcinoma
• tumors are highly apoptotic compared to tumors from Tg(MMTV-PyVT)634Mul single mutants
• tumor angiogenesis is decreased relative to tumors from Tg(MMTV-PyVT)634Mul single mutants

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory