Phenotypes Associated with This Genotype

Genotype
MGI:4361929

• Allelic Composition: Shc1^tm5Paw/Shc1^tm5Paw; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:133325 )

• cells of hyperplastic lesions show a significant reduction of percentage of proliferating cells but no drastic increase in apoptotic cell number in mammary glands of 8-week old females

• tumor angiogenesis assessed by microvessel density is significantly decreaed relative to tumors from Tg(MMTV-PyVT)634Mul single mutants, along with increased level of ischemic necrosis

decreased metastatic potential ( J:133325 )

• number of mice displaying lung metastases is decreased by greater than 3-fold compared to Tg(MMTV-PyVT)634Mul single mutants (24 vs 91 mice)

increased tumor latency ( J:133325 )

• mammary tumor latency is strongly increased compared to Tg(MMTV-PyVT)634Mul single mutants (155 days vs 66 days)

endocrine/exocrine glands

abnormal mammary gland morphology ( J:133325 )

♀ • entire gland is hyperplastic

♀ • mammary glands are composed of single layer of epithelial cells surrounding a dilated lumen

increased mammary gland tumor incidence ( J:133325 )

• cells of hyperplastic lesions show a significant reduction of percentage of proliferating cells but no drastic increase in apoptotic cell number in mammary glands of 8-week old females

• tumor angiogenesis assessed by microvessel density is significantly decreaed relative to tumors from Tg(MMTV-PyVT)634Mul single mutants, along with increased level of ischemic necrosis

integument

abnormal mammary gland morphology ( J:133325 )

♀ • entire gland is hyperplastic

♀ • mammary glands are composed of single layer of epithelial cells surrounding a dilated lumen

increased mammary gland tumor incidence ( J:133325 )

• cells of hyperplastic lesions show a significant reduction of percentage of proliferating cells but no drastic increase in apoptotic cell number in mammary glands of 8-week old females

• tumor angiogenesis assessed by microvessel density is significantly decreaed relative to tumors from Tg(MMTV-PyVT)634Mul single mutants, along with increased level of ischemic necrosis