Phenotypes Associated with This Genotype

Genotype
MGI:4361927

• Allelic Composition: Shc1^tm6Paw/Shc1⁺; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:133325 )

• tumor nodules are present throughout the entire mammary gland

• combination of adenomas and cystic hyperplasias are seen in mammary glands

• tumor angiogenesis assessed by microvessel density is significantly decreaed relative to tumors from Tg(MMTV-PyVT)634Mul single mutants, along with increased level of ischemic necrosis

decreased metastatic potential ( J:133325 )

• number of mice displaying lung metastases is decreased compared to Tg(MMTV-PyVT)634Mul single mutants (58 vs 91 mice)

increased tumor latency ( J:133325 )

• mammary tumor onset is modestly delayed compared to Tg(MMTV-PyVT)634Mul single mutants (86 days vs 66 days)

endocrine/exocrine glands

abnormal mammary gland morphology ( J:133325 )

♀ • tumor nodules are present throughout the entire mammary gland

♀ • combination of adenomas and cystic hyperplasias are seen in mammary glands

increased mammary gland tumor incidence ( J:133325 )

• tumor nodules are present throughout the entire mammary gland

• combination of adenomas and cystic hyperplasias are seen in mammary glands

• tumor angiogenesis assessed by microvessel density is significantly decreaed relative to tumors from Tg(MMTV-PyVT)634Mul single mutants, along with increased level of ischemic necrosis

integument

abnormal mammary gland morphology ( J:133325 )

♀ • tumor nodules are present throughout the entire mammary gland

♀ • combination of adenomas and cystic hyperplasias are seen in mammary glands

increased mammary gland tumor incidence ( J:133325 )

• tumor nodules are present throughout the entire mammary gland

• combination of adenomas and cystic hyperplasias are seen in mammary glands

• tumor angiogenesis assessed by microvessel density is significantly decreaed relative to tumors from Tg(MMTV-PyVT)634Mul single mutants, along with increased level of ischemic necrosis