Phenotypes Associated with This Genotype

Genotype
MGI:4361926

• Allelic Composition: Shc1^tm7Paw/Shc1⁺; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:133325 )

• glands contain combination of tumor and hyperplastic structures

• combination of adenomas and cystic hyperplasias are seen in mammary glands

• tumor angiogenesis is decreased relative to tumors from Tg(MMTV-PyVT)634Mul single mutants

decreased metastatic potential ( J:133325 )

• number of mice displaying lung metastases is decreased compared to Tg(MMTV-PyVT)634Mul single mutants (60 vs 91 mice)

increased tumor latency ( J:133325 )

• mammary tumor latency is strongly increased compared to Tg(MMTV-PyVT)634Mul single mutants (95 days vs 66 days)

endocrine/exocrine glands

abnormal mammary gland morphology ( J:133325 )

♀ • glands contain combination of tumor and hyperplastic structures

increased mammary gland tumor incidence ( J:133325 )

• glands contain combination of tumor and hyperplastic structures

• combination of adenomas and cystic hyperplasias are seen in mammary glands

• tumor angiogenesis is decreased relative to tumors from Tg(MMTV-PyVT)634Mul single mutants

integument

abnormal mammary gland morphology ( J:133325 )

♀ • glands contain combination of tumor and hyperplastic structures

increased mammary gland tumor incidence ( J:133325 )

• glands contain combination of tumor and hyperplastic structures

• combination of adenomas and cystic hyperplasias are seen in mammary glands

• tumor angiogenesis is decreased relative to tumors from Tg(MMTV-PyVT)634Mul single mutants