Phenotypes Associated with This Genotype

Genotype
MGI:4361876

• Allelic Composition: Aprt^tm1Jat/Aprt^tm1Jat; Spp1^tm1Rit/Spp1^tm1Rit
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:114314 )

• fewer than expected female pups are observed (no time point of death given)

renal/urinary system

abnormal urine nucleoside level ( J:114314 )

• at 12 weeks, purine excretion in male mice is higher than in Aprt^tm1Jat homozygotes

abnormal kidney morphology ( J:114314 )

• at 12 weeks, female mice exhibit a more severe renal pathology than Aprt^tm1Jat homozygotes

growth/size/body

abnormal body weight ( J:114314 )

• growth curve analysis indicates that female mice are smaller at young ages but exhibit rapid weight gain in order to achieve normal maximal weight

decreased body weight ( J:114314 )

• in male mice compared with Aprt^tm1Jat homozygotes

homeostasis/metabolism

abnormal urine nucleoside level ( J:114314 )

• at 12 weeks, purine excretion in male mice is higher than in Aprt^tm1Jat homozygotes