Phenotypes for Apoe Spp1 MGI:4361864 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Spp1^tm1Rit/Spp1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (35 available); any Apoe mutation (164 available)
Spp1^tm1Rit mutation (6 available); any Spp1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:103051 )

• atherosclerotic lesions in female mice are 43% smaller than in Apoe^tm1Unc homozygotes with reduced aortic wall inflammation

homeostasis/metabolism

increased circulating cholesterol level ( J:103051 )

• total circulating cholesterol and non-HDL-cholesterol levels are increased in male mice compared to in Apoe^tm1Unc homozygotes

increased circulating triglyceride level ( J:103051 )

• in male mice compared to in Apoe^tm1Unc homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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