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Phenotypes Associated with This Genotype
Genotype
MGI:4361864
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Spp1tm1Rit/Spp1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (163 available)
Spp1tm1Rit mutation (6 available); any Spp1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased susceptibility to atherosclerosis ( J:103051 )
• atherosclerotic lesions in female mice are 43% smaller than in Apoetm1Unc homozygotes with reduced aortic wall inflammation

homeostasis/metabolism
increased circulating cholesterol level ( J:103051 )
• total circulating cholesterol and non-HDL-cholesterol levels are increased in male mice compared to in Apoetm1Unc homozygotes
increased circulating triglyceride level ( J:103051 )
• in male mice compared to in Apoetm1Unc homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory