Phenotypes Associated with This Genotype

Genotype
MGI:4361863

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Spp1^tm1Rit/Spp1^tm1Rit
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:103051 )

• atherosclerotic lesions in female mice are 34% smaller than in Apoe^tm1Unc homozygotes

calcified artery ( J:103051 )

• male mice exhibit increased vascular calcification of aortic root sections compared to in Apoe^tm1Unc homozygotes

homeostasis/metabolism

increased circulating cholesterol level ( J:103051 )

• total circulating cholesterol and non-HDL-cholesterol levels are increased 1.5-fold in male mice compared to in Apoe^tm1Unc homozygotes

increased circulating triglyceride level ( J:103051 )

• plasma triglyceride levels are increased 4-fold in male mice compared to in Apoe^tm1Unc homozygotes