Phenotypes Associated with This Genotype

Genotype
MGI:4361714

• Allelic Composition: Spp1^tm1Blh/Spp1^tm1Blh; Umod^tm1Xrw/Umod^tm1Xrw
• Genetic Background: 129S/SvEv-Spp1^tm1Blh Umod^tm1Xrw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased urine phosphate level ( J:127526 )

• urine phosphorus and calcium phosphate content are higher than in wild-type mice

increased urine uric acid level ( J:127526 )

crystalluria ( J:127526 )

• under hyperoxaluria conditions, 95% of mice exhibit large amounts of calcium crystalluria and renal calcium crystal formation unlike similarly treated wild-type mice

• after 1 month of hyperoxaluria, 18% of mice develop large crystalline deposits at the tip of the renal papillae that can block the proximal portions of the collecting ducts unlike similarly treated wild-type mice

• following hyperoxaluria, mice develop stones unlike similarly treated wild-type mice

dilated kidney collecting duct ( J:127526 )

• in some mice after 1 month of hyperoxaluria

nephrocalcinosis ( J:127526 )

• 39% of mice exhibit calcifications in the renal papilla unlike wild-type mice

• renal epithelial cells exhibit a 3.5-fold increase in crystal adhesion to epithelial cells compared with wild-type cells

• 95% of mice exposed to hyperoxaluria develop renal calcinosis unlike similarly treated wild-type mice

renal fibrosis ( J:127526 )

• following hyperoxaluria, mice exhibit greater renal damage and fibrosis than similarly treated wild-type mice

homeostasis/metabolism

increased urine phosphate level ( J:127526 )

• urine phosphorus and calcium phosphate content are higher than in wild-type mice

increased urine uric acid level ( J:127526 )

crystalluria ( J:127526 )

• under hyperoxaluria conditions, 95% of mice exhibit large amounts of calcium crystalluria and renal calcium crystal formation unlike similarly treated wild-type mice

• after 1 month of hyperoxaluria, 18% of mice develop large crystalline deposits at the tip of the renal papillae that can block the proximal portions of the collecting ducts unlike similarly treated wild-type mice

• following hyperoxaluria, mice develop stones unlike similarly treated wild-type mice