Phenotypes Associated with This Genotype

Genotype
MGI:4361711

• Allelic Composition: Spp1^tm1Blh/Spp1^tm1Blh
• Genetic Background: 129S/SvEv-Spp1^tm1Blh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

decreased urine chloride ion level ( J:127526 )

• urine chloride content is lower than in wild-type mice

• however, mice exhibit normal urine creatinine, calcium, magnesium, and citrate levels

decreased urine sodium level ( J:127526 )

crystalluria ( J:127526 )

• under hyperoxaluria conditions, 65% of mice exhibit small amounts of calcium crystalluria and renal calcium crystal formation unlike similarly treated wild-type mice

nephrocalcinosis ( J:127526 )

• 10% of mice exhibit calcifications in the renal papilla unlike wild-type mice

• renal epithelial cells exhibit a 3-fold increase in crystal adhesion to epithelial cells compared with wild-type cells

• 65% of mice exposed to hyperoxaluria develop renal calcinosis unlike similarly treated wild-type mice

homeostasis/metabolism

decreased urine chloride ion level ( J:127526 )

• urine chloride content is lower than in wild-type mice

• however, mice exhibit normal urine creatinine, calcium, magnesium, and citrate levels

decreased urine sodium level ( J:127526 )

crystalluria ( J:127526 )

• under hyperoxaluria conditions, 65% of mice exhibit small amounts of calcium crystalluria and renal calcium crystal formation unlike similarly treated wild-type mice