Phenotypes Associated with This Genotype

Genotype
MGI:4361701

• Allelic Composition: Spp1^tm1Blh/Spp1^tm1Blh
• Genetic Background: 129S6/SvEvTac-Spp1^tm1Blh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:112122 )

• DMBA and TPA-treated mice exhibit delayed tumor development and reduced skin tumor multiplicity compared with similarly treated wild-type mice

• DMBA and TPA-treated male mice exhibit delayed development of tumor/papilloma appearance compared with similarly treated wild-type mice

• DMBA and TPA-induced tumors exhibit increased apoptosis compared to in similarly treated wild-type mice

• however, DMBA and TPA-induced cell proliferation is normal

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:112122 )

• DMBA and TPA-treated mice exhibit delayed tumor development and reduced skin tumor multiplicity compared with similarly treated wild-type mice

• DMBA and TPA-treated male mice exhibit delayed development of tumor/papilloma appearance compared with similarly treated wild-type mice

• DMBA and TPA-induced tumors exhibit increased apoptosis compared to in similarly treated wild-type mice

• however, DMBA and TPA-induced cell proliferation is normal