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Phenotypes Associated with This Genotype
Genotype
MGI:4361698
Allelic
Composition		 Spp1tm1Blh/Spp1+
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1tm1Blh mutation (2 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte migration ( J:86531 )
• leukocytes exhibit decreased basal and MCP-1-dependent migration compared with similarly treated wild-type cells

cellular
abnormal leukocyte migration ( J:86531 )
• leukocytes exhibit decreased basal and MCP-1-dependent migration compared with similarly treated wild-type cells

hematopoietic system
abnormal leukocyte migration ( J:86531 )
• leukocytes exhibit decreased basal and MCP-1-dependent migration compared with similarly treated wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory