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Phenotypes Associated with This Genotype
Genotype
MGI:4361696
Allelic
Composition		 \Apoetm1Unc/\Apoetm1Unc
\Spp1tm1Blh/\Spp1tm1Blh
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (163 available)
Spp1tm1Blh mutation (2 available); any Spp1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased susceptibility to atherosclerosis ( J:86531 )
• Angiotensin II-induced atherosclerotic lesions exhibit reduced medial inflammation, lesion area, cellularity, macrophage viability, and foam cells compared to in similarly treated Apoetm1Unc homozygotes
• however, untreated aged male mice exhibit normal atherosclerotic lesion development
decreased susceptibility to induced aneurysm formation ( J:86531 )
• Angiotensin II-treated mice exhibit reduced abdominal aortic aneurysm incidence and diameter compared with similarly treated Apoetm1Unc homozygotes

immune system
abnormal macrophage physiology ( J:86531 )
• macrophage viability in Angiotensin II-treated mice is lower than in similarly treated Apoetm1Unc homozygotes

hematopoietic system
abnormal macrophage physiology ( J:86531 )
• macrophage viability in Angiotensin II-treated mice is lower than in similarly treated Apoetm1Unc homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory