Phenotypes Associated with This Genotype

Genotype
MGI:4361669

• Allelic Composition: Spp1^tm1Blh/Spp1^tm1Blh
• Genetic Background: BKSW.129S6-Spp1^tm1Blh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immune system physiology ( J:113585 )

• the foreign body response provoked by glutaraldehyde-fixed aortic valve leaflets is diminished in quality with a 50% to 25% reduction in macrophage recruitment, a four- to five-fold increase calcification of the leaflet, and acidification of the leaflet compared to in similarly treated wild-type mice

impaired macrophage chemotaxis ( J:113585 )

• mice exhibit a 50% to 25% reduction in macrophage recruitment to a transplanted glutaraldehyde-fixed aortic valve leaflet compared to in similarly treated wild-type mice

cellular

impaired macrophage chemotaxis ( J:113585 )

• mice exhibit a 50% to 25% reduction in macrophage recruitment to a transplanted glutaraldehyde-fixed aortic valve leaflet compared to in similarly treated wild-type mice

cardiovascular system

calcified aortic valve cusp ( J:113585 )

• the foreign body response provoked by glutaraldehyde-fixed aortic valve leaflets is diminished in quality with a four- to five-fold increase calcification of the leaflet compared to in similarly treated wild-type mice

hematopoietic system

impaired macrophage chemotaxis ( J:113585 )

• mice exhibit a 50% to 25% reduction in macrophage recruitment to a transplanted glutaraldehyde-fixed aortic valve leaflet compared to in similarly treated wild-type mice