Phenotypes Associated with This Genotype

Genotype
MGI:4361629

• Allelic Composition: Spp1^tm1Blh/Spp1^tm1Blh
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased dendritic cell number ( J:119298 )

• mice sensitized with TNCB and challenged hapten exhibit reduced numbers of CD11c+FITC+ cells in the skin draining lymph nodes compared with similarly treated wild-type mice

abnormal immune system physiology ( J:119298 )

• 75% less injected wild-type dendritic cells enter the axillary and inguinal lymph nodes

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:119298 )

• mice sensitized with TNCB and challenged hapten exhibit reduced ear swelling and reduced numbers of CD11c+FITC+ cells in the skin draining lymph nodes compared with similarly treated wild-type mice

hematopoietic system

decreased dendritic cell number ( J:119298 )

• mice sensitized with TNCB and challenged hapten exhibit reduced numbers of CD11c+FITC+ cells in the skin draining lymph nodes compared with similarly treated wild-type mice