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Phenotypes Associated with This Genotype
Genotype
MGI:4361526
Allelic
Composition
Ifngr1tm1Agt/Ifngr1tm1Agt
Genetic
Background
B6.129S7-Ifngr1tm1Agt/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngr1tm1Agt mutation (12 available); any Ifngr1 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• after induction of graft versus host disease

cellular
• reduction of Runx2 expression in bone marrow cells indicating impaired osteoblast differentiation
• reduction of alkaline phosphatase-expressing cells (osteoblasts) indicating impaired late differentiation of osteoblasts
• reduction of RANKL expression in bone marrow cells, indicating impaired osteoclast differentiation

immune system
• reduction of RANKL expression in bone marrow cells, indicating impaired osteoclast differentiation
• after induction of graft versus host disease, mice exhibit reduced numbers and proliferation of CD8+, CD4+, CD11b+, and CD19+ cells in the spleen compared with similarly treated wild-type cells
• after induction of graft versus host disease, mice exhibit reduced numbers of CD8+, CD4+, CD11b+, and CD19+ cells in the spleen compared with similarly treated wild-type cells
• after induction of graft versus host disease
• after induction of graft versus host disease
• after induction of graft versus host disease
• alphaGalCer-treated mice fail to exhibit an increase in circulating CXCL9 unlike similarly treated wild-type mice
• 6 hours following treatment with alphaGalCer compared to in similarly treated wild-type mice
• in the spleen and bone marrow after induction of graft versus host disease
• bacille Calmette-Guerin (BCG)-inoculated mice exhibit reduced depressive-like behavior in a forced swim and tail suspension tests and indoleamine 2,3-dioxygenase (IDO) activity compared with similarly treated wild-type mice
• after induction of graft versus host disease, mice exhibit early mortality, increased lung and skin pathology but decreased intestine pathology, increased IFN-gamma production in the spleen and bone marrow, increased spleen and bone marrow aplasia, decreased proliferation of hematopoietic stem/progenitor cells, and decreased lymphopoiesis compared with similarly treated wild-type mice

skeleton
• reduction of Runx2 expression in bone marrow cells indicating impaired osteoblast differentiation
• reduction of alkaline phosphatase-expressing cells (osteoblasts) indicating impaired late differentiation of osteoblasts
• reduction of RANKL expression in bone marrow cells, indicating impaired osteoclast differentiation
• 45% reduction in bone volume
• mean number of osteocytes per cortical bone at the metaphyseal level is lower
• reduction of mineralized surfaces of bone of 4 week old mice
• reduction in mineral-apposition rate in 4 week old mice
• reduction of osteopontin expression within the trabeculae and in cortical bone indicating impaired mineralization
• reduction in bone-formation rate in 4 week old mice
• markers of bone resorption (RANKL and N-telopeptide) are reduced

neoplasm
• following treatment with alphaGalCer, mice fail to exhibit a reduction in the number of B16F10 tumors metastasizing to the lungs unlike similarly treated wild-type mice
• mice exhibit increased metastasis of B16F10 tumors to the lungs compared with wild-type mice

homeostasis/metabolism
• lower circulating concentrations of the bone-formation marker osteocalcin
• alphaGalCer-treated mice fail to exhibit an increase in circulating CXCL9 unlike similarly treated wild-type mice
• 6 hours following treatment with alphaGalCer compared to in similarly treated wild-type mice

hematopoietic system
• reduction of RANKL expression in bone marrow cells, indicating impaired osteoclast differentiation
• after induction of graft versus host disease, mice exhibit reduced numbers and proliferation of CD8+, CD4+, CD11b+, and CD19+ cells in the spleen compared with similarly treated wild-type cells
• after induction of graft versus host disease
• after induction of graft versus host disease, mice exhibit reduced numbers of CD8+, CD4+, CD11b+, and CD19+ cells in the spleen compared with similarly treated wild-type cells
• after induction of graft versus host disease
• after induction of graft versus host disease
• after induction of graft versus host disease
• after induction of graft versus host disease, proliferation of hematopoietic stem/progenitor cells compared to in similarly treated wild-type mice

behavior/neurological
• bacille Calmette-Guerin (BCG)-inoculated mice exhibit reduced depressive-like behavior in a forced swim and tail suspension tests compared with similarly treated wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
osteoporosis DOID:11476 OMIM:166710
J:233116


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory