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Phenotypes Associated with This Genotype
Genotype
MGI:4361030
Allelic
Composition
Tg(Col2a1-rtTA,tetO-COMP*)2Jath/0
Genetic
Background
C57BL/6-Tg(Col2a1-rtTA,tetO-COMP*)2Jath
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• doxycycline-treated mice exhibit fewer hypertrophic chondrocytes compared with wild-type mice
• doxycycline-treated mice exhibit retention of extracellular matrix protein and intracellular matrix formation in the ribosomal endoplasmic reticulum cisternae in the growth plate unlike in wild-type mice
• in doxycycline-treated mice
• doxycycline-treated mice exhibit an increase in apoptosis in the growth plate compared to in wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Pseudoachondroplasia; PSACH 177170 J:152756


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory