Mouse Genome Informatics
tg
    Tg(Col2a1-rtTA,tetO-COMP*)2Jath/0
C57BL/6-Tg(Col2a1-rtTA,tetO-COMP*)2Jath
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
skeleton
• doxycycline-treated mice exhibit fewer hypertrophic chondrocytes compared with wild-type mice
• doxycycline-treated mice exhibit retention of extracellular matrix protein and intracellular matrix formation in the ribosomal endoplasmic reticulum cisternae in the growth plate unlike in wild-type mice
• in doxycycline-treated mice
• doxycycline-treated mice exhibit an increase in apoptosis in the growth plate compared to in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Pseudoachondroplasia; PSACH 177170 J:152756