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Phenotypes Associated with This Genotype
Genotype
MGI:4361030
Allelic
Composition
Tg(Col2a1-rtTA,tetO-COMP*)2Jath/0
Genetic
Background
C57BL/6-Tg(Col2a1-rtTA,tetO-COMP*)2Jath
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• doxycline exposure in the prenatal period to P7 evokes very little growth plate chondrocyte death, however doxycycline exposure in the prenatal period to P14, P21 or P28, increases growth plate chondrocyte death

skeleton
• doxycycline treated mice show a reduction in the size of the skeleton by P7 and are 12% shorter at P28, at which time it is most marked
• total skull length is reduced by 10% in doxycycline treated mice
• however, intercanthal distance is normal
• exaggerated curvature in the thoracic and lumbar spine is seen in most doxycycline treated mice by P28
• doxycline exposure in the prenatal period to P14, P21, or P28 increases growth plate chondrocyte death and doxycline exposure to P21 or P28 results in increased inflammation in the growth plate
• treatment with lithium reduces pup viability and disrupts growth plate organization
• treatment of doxycycline-administered mice with valproate reduces apoptosis by about 50% and improves growth plate architecture, however skull and limb lengths are reduced by another 9%
• treatment of doxycycline-administered mice with phenylbutyric acid only minimally reduces apoptosis in the growth plate
• doxycycline-treated mice exhibit fewer hypertrophic chondrocytes compared with wild-type mice
• doxycycline-treated mice exhibit retention of extracellular matrix protein and intracellular matrix formation in the ribosomal endoplasmic reticulum cisternae in the growth plate unlike in wild-type mice
• in doxycycline-treated mice
• doxycycline-treated mice exhibit an increase in apoptosis in the growth plate compared to in wild-type mice
• doxycline exposure in the prenatal period to P7 evokes very little growth plate chondrocyte death, however doxycycline exposure in the prenatal period to P14, P21 or P28, increases growth plate chondrocyte death

craniofacial
• total skull length is reduced by 10% in doxycycline treated mice
• however, intercanthal distance is normal
• an increase in cartilage is seen in the snout of P21 and P28 doxycycline treated mice
• total snout length is reduced by 15% in doxycycline treated mice

growth/size/body
• an increase in cartilage is seen in the snout of P21 and P28 doxycycline treated mice
• total snout length is reduced by 15% in doxycycline treated mice
• doxycycline treated mice show a marked progression in the development of pectus carinatum at P28

immune system
• inflammation as analyzed by markers develops in the growth plate when mice are exposed to doxycycline from conception to P21 or P28, but not when they are only exposed to it to E15.5, P1, P7 or P14
• exercise in doxycycline treated mice exacerbates inflammation in the articular cartilage

Mouse Models of Human Disease
OMIM ID Ref(s)
Pseudoachondroplasia; PSACH 177170 J:152756 , J:233238


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory