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Phenotypes Associated with This Genotype
Genotype
MGI:4360762
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Notch2tm1.1Hhi/Notch2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Notch2tm1.1Hhi mutation (1 available); any Notch2 mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased marginal zone B cell number ( J:83476 )
• numbers of marginal zone B cells in the spleen are 1/6 to 1/4 of those in the control mice
• IgM+IgD- marginal zone B cells are reduced in the spleen

immune system
decreased marginal zone B cell number ( J:83476 )
• numbers of marginal zone B cells in the spleen are 1/6 to 1/4 of those in the control mice
• IgM+IgD- marginal zone B cells are reduced in the spleen

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory