Phenotypes Associated with This Genotype

Genotype
MGI:4360680

• Allelic Composition: Ikzf1^tm2Kge/Ikzf1^tm2Kge
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:37317 )

• thymus and T cell proliferation in response to TCR stimulation is enhanced in these mice

absent Peyer's patches ( J:37317 )

• Peyer's patches lymphoid follicles are absent in these mice

abnormal thymus development ( J:37317 )

• thymus development is delayed in these mice

• thymus morphology at birth is similar to day 13-14 fetal thymus in controls

• the thymus only begins to develop cortical and medullary structures in the first week of life

• between 2-6 of weeks of age, thymus size dramatically increases so that in some cases the thymus is similar in size to controls

• thymic dendritic antigen-presenting-cells are virtually absent

thymus hypoplasia ( J:37317 )

• thymocyte number is low at birth but increases with age

• thymocyte numbers are 100- to 300- fold lower than controls between 3 and 6 days of age

• numbers increase between 2 and 6 weeks after birth so that thymocyte numbers range from 5- fold lower to normal

absent pro-B cells ( J:37317 )

• pro-B cells are absent in the bone marrow

abnormal T cell differentiation ( J:208211 , J:37317 )

• mice exhibit skewing towards the CD4+ lineage (J:208211)

• fetal T cell development is severely impaired leading to a defect in gamma-delta intraepithelial lymphocyte development (J:37317)

decreased double-positive T cell number ( J:37317 )

• double-positive thymocyte numbers are decreased in these mice

decreased granulocyte number ( J:37317 )

• granulocyte numbers in the bone marrow are decreased compared to control

abnormal dendritic cell number ( J:37317 )

• thymic dendritic antigen-presenting-cells are virtually absent

decreased plasmacytoid dendritic cell number ( J:208211 )

• absent

absent B-1a cells ( J:37317 )

• B-1a B cells are absent in the peritoneum

absent B cells ( J:208211 , J:37317 )

• B cells are absent in the periphery (J:37317)

absent pre-B cells ( J:37317 )

• pre-B cells are absent in the bone marrow

absent NK cells ( J:208211 , J:37317 )

• NK cells are absent in the spleen (J:37317)

decreased mature gamma-delta T cell number ( J:37317 )

• no significant gamma-delta T cell population is found in the spleen

decreased gamma-delta intraepithelial T cell number ( J:37317 )

• mice lack dendritic epidermal T cells in the skin

• intraepithelial gamma-delta T cell numbers in the intestine are severely reduced

• vagina mucosal gamma-delta T cell numbers are normal

abnormal splenic cell ratio ( J:37317 )

• ratio of CD4⁺ to CD8⁺ T cells varies from being similar to wild-type to being increased by 2- to 3- fold

decreased splenocyte number ( J:37317 )

• splenocyte numbers are low at birth but increase with age

absent mesenteric lymph nodes ( J:37317 )

absent axillary lymph nodes ( J:37317 )

absent cervical lymph nodes ( J:37317 )

absent inguinal lymph nodes ( J:37317 )

hematopoietic system

increased T cell proliferation ( J:37317 )

• thymus and T cell proliferation in response to TCR stimulation is enhanced in these mice

abnormal thymus development ( J:37317 )

• thymus development is delayed in these mice

• thymus morphology at birth is similar to day 13-14 fetal thymus in controls

• the thymus only begins to develop cortical and medullary structures in the first week of life

• between 2-6 of weeks of age, thymus size dramatically increases so that in some cases the thymus is similar in size to controls

• thymic dendritic antigen-presenting-cells are virtually absent

thymus hypoplasia ( J:37317 )

• thymocyte number is low at birth but increases with age

• thymocyte numbers are 100- to 300- fold lower than controls between 3 and 6 days of age

• numbers increase between 2 and 6 weeks after birth so that thymocyte numbers range from 5- fold lower to normal

abnormal erythropoiesis ( J:37317 )

• the abnormal erythropoiesis associated with mice homozygote for the dominant-negative Ikzf1^tm1Kge allele are not observed in these mice

absent pro-B cells ( J:37317 )

• pro-B cells are absent in the bone marrow

abnormal T cell differentiation ( J:208211 , J:37317 )

• mice exhibit skewing towards the CD4+ lineage (J:208211)

• fetal T cell development is severely impaired leading to a defect in gamma-delta intraepithelial lymphocyte development (J:37317)

decreased double-positive T cell number ( J:37317 )

• double-positive thymocyte numbers are decreased in these mice

decreased granulocyte number ( J:37317 )

• granulocyte numbers in the bone marrow are decreased compared to control

abnormal dendritic cell number ( J:37317 )

• thymic dendritic antigen-presenting-cells are virtually absent

decreased plasmacytoid dendritic cell number ( J:208211 )

• absent

absent B-1a cells ( J:37317 )

• B-1a B cells are absent in the peritoneum

absent B cells ( J:208211 , J:37317 )

• B cells are absent in the periphery (J:37317)

absent pre-B cells ( J:37317 )

• pre-B cells are absent in the bone marrow

absent NK cells ( J:208211 , J:37317 )

• NK cells are absent in the spleen (J:37317)

decreased mature gamma-delta T cell number ( J:37317 )

• no significant gamma-delta T cell population is found in the spleen

decreased gamma-delta intraepithelial T cell number ( J:37317 )

• mice lack dendritic epidermal T cells in the skin

• intraepithelial gamma-delta T cell numbers in the intestine are severely reduced

• vagina mucosal gamma-delta T cell numbers are normal

abnormal splenic cell ratio ( J:37317 )

• ratio of CD4⁺ to CD8⁺ T cells varies from being similar to wild-type to being increased by 2- to 3- fold

decreased splenocyte number ( J:37317 )

• splenocyte numbers are low at birth but increase with age

endocrine/exocrine glands

abnormal thymus development ( J:37317 )

• thymus development is delayed in these mice

• thymus morphology at birth is similar to day 13-14 fetal thymus in controls

• the thymus only begins to develop cortical and medullary structures in the first week of life

• between 2-6 of weeks of age, thymus size dramatically increases so that in some cases the thymus is similar in size to controls

• thymic dendritic antigen-presenting-cells are virtually absent

thymus hypoplasia ( J:37317 )

• thymocyte number is low at birth but increases with age

• thymocyte numbers are 100- to 300- fold lower than controls between 3 and 6 days of age

• numbers increase between 2 and 6 weeks after birth so that thymocyte numbers range from 5- fold lower to normal

cellular

increased T cell proliferation ( J:37317 )

• thymus and T cell proliferation in response to TCR stimulation is enhanced in these mice

digestive/alimentary system

absent Peyer's patches ( J:37317 )

• Peyer's patches lymphoid follicles are absent in these mice