Phenotypes Associated with This Genotype

Genotype
MGI:4360345

• Allelic Composition: Lck^tm1Mak/Lck^tm1Mak; Rag1^tm1Mom/Rag1⁺; Tg(Lck-Fyn*Y528F)5525Cjg/0
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:37062 )

• the transgene partially rescues arrest of T cell development associated with Lck deficiency

• thymocyte numbers are normal

• splenic gamma-delta T cell numbers are normal

• expression of TCR and CD5 on transitional single-positive thymocytes is slightly lower than controls

decreased T cell number ( J:37062 )

• alpha beta T cell numbers are less than half of wild-type controls

immune system

abnormal T cell differentiation ( J:37062 )

• the transgene partially rescues arrest of T cell development associated with Lck deficiency

• thymocyte numbers are normal

• splenic gamma-delta T cell numbers are normal

• expression of TCR and CD5 on transitional single-positive thymocytes is slightly lower than controls

decreased T cell number ( J:37062 )

• alpha beta T cell numbers are less than half of wild-type controls