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Phenotypes Associated with This Genotype
Genotype
MGI:4360118
Allelic
Composition		 Srrttm1.1Thsn/Srrttm1.2Thsn
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srrttm1.1Thsn mutation (0 available); any Srrt mutation (55 available)
Srrttm1.2Thsn mutation (0 available); any Srrt mutation (55 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased splenocyte apoptosis ( J:152729 )
• in pIpC-treated mice
abnormal thymus physiology ( J:152729 )
• pIpC-treated mice exhibit increased thymic apoptosis compared with Srrttm1.1Thsn/Srrttm1.2Thsn control mice
decreased bone marrow cell number ( J:152729 )
• in pIpC-treated mice

immune system
increased splenocyte apoptosis ( J:152729 )
• in pIpC-treated mice
abnormal thymus physiology ( J:152729 )
• pIpC-treated mice exhibit increased thymic apoptosis compared with Srrttm1.1Thsn/Srrttm1.2Thsn control mice

cellular
increased splenocyte apoptosis ( J:152729 )
• in pIpC-treated mice

endocrine/exocrine glands
abnormal thymus physiology ( J:152729 )
• pIpC-treated mice exhibit increased thymic apoptosis compared with Srrttm1.1Thsn/Srrttm1.2Thsn control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory