cardiovascular system
• neointimal lesions are observed in 18-month old arteries
• lesions form between the lamina elastica and the endothelial cells
• lesions can grow to large volumes that thin the media without constricting the vessel
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• the contractility of femorial arterial smooth muscle is 39% less than controls after depolarization by potassium
• maximum Ca2+-induced vasoconstriction is blunted by about 30%
• arterial smooth muscle fails to contract in response to angiotensin II stimulation and only respond poorly to alpha1-adrenoceptor agonist phenylephrine
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• thickness of the smooth muscle cell layer in the femoral artery is reduced by about a third
• reduced thickness of the smooth muscle cell layer in femoral artery is due to smaller size of the smooth muscles cells
• the aorta showed a similar though less severe phenotype
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• diastolic blood pressure under anesthesia is reduced by about 30%
• similar results are observed in awake mice
• angiotensin II administration fails to increase blood pressure to the same extent as in controls
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• systolic blood pressure under anesthesia is reduced by about 14%
• similar results are observed in awake mice
• angiotensin II administration fails to increase blood pressure to the same extent as in controls
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• the contractility of femorial arterial smooth muscle is 39% less than controls after depolarization by potassium
• maximum Ca2+-induced vasoconstriction is blunted by about 30%
• arterial smooth muscle fails to contract in response to angiotensin II stimulation and only respond poorly to alpha1-adrenoceptor agonist phenylephrine
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• neointimal lesions with macrophages and smooth muscle cells are observed in 18-month old arteries
• lesions form between the lamina elastica and the endothelial cells
• lesions can grow to large volumes that thin the media without constricting the vessel
|
homeostasis/metabolism
• neointimal lesions with macrophages and smooth muscle cells are observed in 18-month old arteries
• lesions form between the lamina elastica and the endothelial cells
• lesions can grow to large volumes that thin the media without constricting the vessel
|
muscle
• the contractility of femorial arterial smooth muscle is 39% less than controls after depolarization by potassium
• maximum Ca2+-induced vasoconstriction is blunted by about 30%
• arterial smooth muscle fails to contract in response to angiotensin II stimulation and only respond poorly to alpha1-adrenoceptor agonist phenylephrine
|
• thickness of the smooth muscle cell layer in the femoral artery is reduced by about a third
• reduced thickness of the smooth muscle cell layer in femoral artery is due to smaller size of the smooth muscles cells
• the aorta showed a similar though less severe phenotype
|
• the contractility of femorial arterial smooth muscle is 39% less than controls after depolarization by potassium
• maximum Ca2+-induced vasoconstriction is blunted by about 30%
• arterial smooth muscle fails to contract in response to angiotensin II stimulation and only respond poorly to alpha1-adrenoceptor agonist phenylephrine
|