Phenotypes Associated with This Genotype

Genotype
MGI:4359886

• Allelic Composition: Slc30a8^tm1Lex/Slc30a8^tm1Lex
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:152629 )

N • despite reduction in serum insulin levels, mice exhibit normal whole-body glucose metabolism

decreased insulin secretion ( J:152629 )

• glucose-stimulated insulin secretion is reduced 33% compared to in similarly treated wild-type cells

decreased circulating insulin level ( J:152629 )

abnormal zinc homeostasis ( J:152629 )

• zinc content in islets is reduced compared to in wild-type cells

endocrine/exocrine glands

decreased insulin secretion ( J:152629 )

• glucose-stimulated insulin secretion is reduced 33% compared to in similarly treated wild-type cells