Phenotypes Associated with This Genotype

Genotype
MGI:4359631

• Allelic Composition: Tg(Fabp4-Angptl2)5Yo/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

white adipose tissue inflammation ( J:152387 )

• adipose tissue is inflamed as indicated by increased numbers of macrophages, adherent leukocytes in blood vessels within epididymal adipose tissue, and increased mRNA expression of inflammatory cytokines within fat tissue

homeostasis/metabolism

impaired glucose tolerance ( J:152387 )

• glucose tolerance is impaired in tolerance tests and hyperinsulinemic- euglycemic clamp tests

insulin resistance ( J:152387 )

• insulin sensitivity is impaired in tolerance tests and hyperinsulinemic- euglycemic clamp tests

immune system

white adipose tissue inflammation ( J:152387 )

• adipose tissue is inflamed as indicated by increased numbers of macrophages, adherent leukocytes in blood vessels within epididymal adipose tissue, and increased mRNA expression of inflammatory cytokines within fat tissue

abnormal macrophage chemotaxis ( J:152387 )

• increased numbers of macrophages are found in adipose tissue

chronic inflammation ( J:152387 )

• adipose tissue is inflamed as indicated by increased numbers of macrophages, adherent leukocytes within adipose blood vessels and increased mRNA expression of inflammatory cytokines within fat tissue

cellular

abnormal macrophage chemotaxis ( J:152387 )

• increased numbers of macrophages are found in adipose tissue

hematopoietic system

abnormal macrophage chemotaxis ( J:152387 )

• increased numbers of macrophages are found in adipose tissue