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Phenotypes Associated with This Genotype
Genotype
MGI:4359221
Allelic
Composition
Slc34a1tm1Hten/Slc34a1tm1Hten
Slc34a3tm1Kimi/Slc34a3tm1Kimi
Genetic
Background
B6.129-Slc34a3tm1Kimi Slc34a1tm1Hten
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc34a1tm1Hten mutation (1 available); any Slc34a1 mutation (3 available)
Slc34a3tm1Kimi mutation (0 available); any Slc34a3 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• marked growth retardation (J:152195)
• marked growth retardation (J:152195)

homeostasis/metabolism
• significantly reduced (J:152195)
• significantly reduced (J:152195)
• severe (J:152195)
• severe (J:152195)
• severe (J:152195)
• severe (J:152195)
• plasma fibroblast growth factor 23 levels reduced (J:152195)
• plasma fibroblast growth factor 23 levels reduced (J:152195)
• abnormal phosphate re-uptake (J:152195)
• abnormal phosphate re-uptake (J:152195)
• plasma levels of 1,25(OH)2 vitamin D3 are elevated at all time points tested (J:152195)
• plasma levels of 1,25(OH)2 vitamin D3 are elevated at all time points tested (J:152195)
• significantly elevated calcium levels in urine (J:152195)
• significantly elevated calcium levels in urine (J:152195)

renal/urinary system
• abnormal phosphate re-uptake (J:152195)
• abnormal phosphate re-uptake (J:152195)
• significantly elevated calcium levels in urine (J:152195)
• significantly elevated calcium levels in urine (J:152195)
• mineral deposition in kidneys (J:152195)
• mineral deposition in kidneys (J:152195)

skeleton
• irregularly arranged metaphyseal trabecules (J:152195)
• irregularly arranged metaphyseal trabecules (J:152195)
• deep growth plate cartilage (J:152195)
• deep growth plate cartilage (J:152195)
• expanded (J:152195)
• expanded (J:152195)
• reduced mineralization of trabecules (J:152195)
• significantly increased osteoid volume/bone volume (J:152195)
• reduced mineralization of trabecules (J:152195)
• significantly increased osteoid volume/bone volume (J:152195)
• develop typical features of rickets (J:152195)
• rescued by a high phosphate diet (J:152195)
• develop typical features of rickets (J:152195)
• rescued by a high phosphate diet (J:152195)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory