Phenotypes for Aplp2 App Chat MGI:4359069 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm1.1Zhe/App^tm1.1Zhe Chat^tm2(cre)Lowl/Chat⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2^tm1Dbo mutation (1 available); any Aplp2 mutation (31 available)
App^tm1.1Zhe mutation (1 available); any App mutation (118 available)
Chat^tm2(cre)Lowl mutation (4 available); any Chat mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuromuscular synapse morphology ( J:152457 )

• at P0, presynaptic and postsynaptic terminal distribution is diffuse and nerve terminal sprouting occurs unlike in wild-type mice that is not as severe as in Aplp2^tm1Dbo App^tm1.2Zhe double homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/06/2026 MGI 6.24