Analysis Tools
reproductive system
| N |
• unlike in other Kit mutants, spermatogenesis is normal
|
immune system
| N |
• steady-state white blood cell numbers are normal
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|
• at 14 months, mice exhibit a reduction in fractions B, C, and D of developing B cells compared to in wild-type mice
• however, the A and F fractions are normal
|
|
• beginning at 6 months and peaking at 9 months, TN1 cells are increased while TN2 and TN3 T cells are decreased compared to in wild-type mice
• at 9 months the TN1 subset is 3-fold larger than in wild-type mice
• the TN2, TN3, and TN4 subsets are decreased 50%
• however, T cell differentiation at later stages is normal
|
|
• at 18 to 24 weeks, peritoneal mast cell numbers are decreased compared to in wild-type mice
• however, the number of dorsal skin mast cells is normal
|
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• the percentage of splenic B cells is slightly increased compared to in wild-type mice
|
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• in culture, KitL-mediated proliferation of bone marrow-derived mast cells is enhanced compared with similarly treated wild-type cells and survival of these cells is marginally enhance
|
pigmentation
|
• mice exhibit variable ventral depigmentation
|
hematopoietic system
| N |
• hematocrit values and red blood cell, white blood cell, and platelet numbers are normal
|
|
• at 14 months, mice exhibit a reduction in fractions B, C, and D of developing B cells compared to in wild-type mice
• however, the A and F fractions are normal
|
|
• beginning at 6 months and peaking at 9 months, TN1 cells are increased while TN2 and TN3 T cells are decreased compared to in wild-type mice
• at 9 months the TN1 subset is 3-fold larger than in wild-type mice
• the TN2, TN3, and TN4 subsets are decreased 50%
• however, T cell differentiation at later stages is normal
|
|
• at 18 to 24 weeks, peritoneal mast cell numbers are decreased compared to in wild-type mice
• however, the number of dorsal skin mast cells is normal
|
|
• the percentage of splenic B cells is slightly increased compared to in wild-type mice
|
|
• in culture, KitL-mediated proliferation of bone marrow-derived mast cells is enhanced compared with similarly treated wild-type cells and survival of these cells is marginally enhance
|
integument
|
• mice exhibit variable ventral depigmentation
|
