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Phenotypes Associated with This Genotype
Genotype
MGI:4358198
Allelic
Composition
Pik3cgtm1Dwu/Pik3cgtm1Dwu
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cgtm1Dwu mutation (1 available); any Pik3cg mutation (59 available)
Tg(TcraTcrb)1100Mjb mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• naive CD8+ T cell activation, proliferation, and differentiation are normal
• following adoptive transfer into wild-type mice and infection with VV-OVA, CD8+ T cells exhibit defective migration into the peritoneum after 8 days compared to when wild-type cells are transferred into a similarly treated host
• however, 4 days after infection CD8+ T cell numbers are normal
• following adoptive transfer into wild-type mice and infection with VV-OVA, CD8+ T cells exhibit defective migration into the peritoneum after 8 days compared to when wild-type cells are transferred into a similarly treated host
• however, 4 days after infection CD8+ T cell numbers are normal

hematopoietic system
• following adoptive transfer into wild-type mice and infection with VV-OVA, CD8+ T cells exhibit defective migration into the peritoneum after 8 days compared to when wild-type cells are transferred into a similarly treated host
• however, 4 days after infection CD8+ T cell numbers are normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory