Phenotypes Associated with This Genotype

Genotype
MGI:4358179

• Allelic Composition: Cd81^tm1Lvy/Cd81^tm1Lvy
• Genetic Background: either: (B6ByJ.129-Cd81^tm1Lvy x CByJ.129-Cd81^tm1Lvy)F1 or (CByJ.129-Cd81^tm1Lvy x B6ByJ.129-Cd81^tm1Lvy)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal CNS glial cell morphology ( J:79426 )

• the glial cell to neuronal cell ratio is significantly increased in the neocortex

• neuronal cell density is decreased while glial cell density is normal indicating increased number of glial cells

increased astrocyte number ( J:79426 )

• there is a significant increase in the number of astrocytes within the hippocampus relative to their control littermates

• astrocyte cell size is not enlarged

abnormal microglial cell morphology ( J:79426 )

• numbers of microglial cells in the hippocampus are increased by 58%

increased brain weight ( J:79426 )

• Background Sensitivity: brains are about 20% heavier than littermate controls on this F1 background while no effect is seen by the null mutation on a C57BL/6 background

• Background Sensitivity: the mean brain weight is 570 mg, which is three standard deviations higher than that of typical mice

abnormal corpus callosum morphology ( J:79426 )

• despite increased brain size, corpus callosum cross sectional area is comparable to controls

abnormal hippocampus morphology ( J:79426 )

abnormal hippocampus CA1 region morphology ( J:79426 )

• mice have a 7.5% increase in the thickness of CA1 relative to the normal littermates

increased hippocampus volume ( J:79426 )

• Background Sensitivity: hippocampus volume is significantly larger unlike on C57BL/6 background where no significant effect is seen

thickened cerebral cortex ( J:79426 )

• Background Sensitivity: the cerebral cortex is thicker than controls on a F1 background which contributes to the increased brain weight of this strain of mice

abnormal neuron morphology ( J:79426 )

• neuronal cell density is decreased due to increased glial cell number

abnormal hippocampus pyramidal cell morphology ( J:79426 )

• there is a greater expanse of the pyramidal cells' dendritic fields

immune system

abnormal microglial cell morphology ( J:79426 )

• numbers of microglial cells in the hippocampus are increased by 58%

hematopoietic system

abnormal microglial cell morphology ( J:79426 )

• numbers of microglial cells in the hippocampus are increased by 58%

cellular

abnormal CNS glial cell morphology ( J:79426 )

• the glial cell to neuronal cell ratio is significantly increased in the neocortex

• neuronal cell density is decreased while glial cell density is normal indicating increased number of glial cells

increased astrocyte number ( J:79426 )

• there is a significant increase in the number of astrocytes within the hippocampus relative to their control littermates

• astrocyte cell size is not enlarged

abnormal microglial cell morphology ( J:79426 )

• numbers of microglial cells in the hippocampus are increased by 58%