Phenotypes Associated with This Genotype

Genotype
MGI:4358135

• Allelic Composition: Tg(EIF1AX-PMS2*)685Tcar/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:152364 )

• cell exhibit microsatellite instability, evident in samples taken from liver and ovary

• total mutation frequency in liver is 1.42%, consisting of expansions and contractions of microsatellites in contrast to none detected in liver samples from wild-type

abnormal mismatch repair ( J:152364 )

• defective mismatch repair (MMR) is exhibited, shown by microsatellite instability

homeostasis/metabolism

abnormal mismatch repair ( J:152364 )

• defective mismatch repair (MMR) is exhibited, shown by microsatellite instability