Tg(EIF1AX-PMS2*)685Tcar
Transgene Detail

Summary

• Symbol: Tg(EIF1AX-PMS2*)685Tcar
• Name: transgene insertion 685, Trent Carrier
• MGI ID: MGI:4357948
• Synonyms: line 685, Morphogene^TM
• Transgene: Tg(EIF1AX-PMS2*)685Tcar Location: unknown
• Alliance: Tg(EIF1AX-PMS2*)685Tcar page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL/J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(EIF1AX-PMS2*)685Tcar expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PMS2 (5395)

  Pms2	(MGI:104288)

• Mutation details: The human EIF1AX (eukaryotic translation initiation factor 1A, X-linked; elongation factor 1A) promoter drives expression of the "Morphogene" transgene which encodes a truncation of the human PMS2 (PMS2 postmeiotic segregation increased 2 (S. cerevisiae)) gene at codon 134 (hPMS2-134). The vector also contains the bovine growth hormone polyA sequence. The transgenic cassette was injected into (C57BL/6 x SJL/J)F2 mouse embryos. Line 685 was established. (J:152364, J:152366)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:152364 Drozdowski B, et al., Generation of a dominant-negative PMS2 transgenic mouse line. MGI Direct Data Submission. 2009
• All: 3 reference(s)