Phenotypes Associated with This Genotype

Genotype
MGI:4358133

• Allelic Composition: Cd81^tm1Lvy/Cd81^tm1Lvy
• Genetic Background: CByJ.129-Cd81^tm1Lvy

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T-helper 2 physiology ( J:46171 )

• peribronchial lymph node lymphocytes from OVA challenged mice produce much less IFN-gamma, IL-4, IL-5 and IL-13 upon restimulation

• splenocytes from OVA-challenged mice produce half the IFN-gamma, IL-4 and IL-13 as controls

• T cells can be differentiated into Th2 effector cells in vitro

decreased susceptibility to type I hypersensitivity reaction ( J:46171 )

• sensitized mice have decreased airway hyperresponsiveness to ova antigen after previously exposure

• mice have much reduced peribronchiolar and perivascular inflammatory infiltrates after OVA challenge with no sign of hypertrophy or mucin

• B cells numbers in peribronchiolar lymph nodes of OVA challenged mice are reduced by about half

nervous system

increased brain weight ( J:79426 )

• Background Sensitivity: there is a modest increase in brain weight compared to littermate controls on while no effect is seen by the null mutation on a C57BL/6 background

increased hippocampus volume ( J:79426 )

• Background Sensitivity: hippocampus volume is slightly larger unlike on C57BL/6 background where no significant effect is seen

thickened cerebral cortex ( J:79426 )

• Background Sensitivity: the cerebral cortex is thicker than controls on a mixed background which contributes to the increased brain weight of this strain of mice

hematopoietic system

abnormal T-helper 2 physiology ( J:46171 )

• peribronchial lymph node lymphocytes from OVA challenged mice produce much less IFN-gamma, IL-4, IL-5 and IL-13 upon restimulation

• splenocytes from OVA-challenged mice produce half the IFN-gamma, IL-4 and IL-13 as controls

• T cells can be differentiated into Th2 effector cells in vitro