Phenotypes Associated with This Genotype

Genotype
MGI:4358061

• Allelic Composition: Pik3cb^tm1.1Ehi/Pik3cb^tm1.1Ehi
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:152332 )

• 50% fewer than expected mice are born

embryonic lethality during organogenesis, incomplete penetrance ( J:152332 )

• 30% of mice are moribund at E13.5

growth/size/body

decreased embryo size ( J:152332 )

• in 30% of mice at E13.5

decreased birth body size ( J:152332 )

postnatal growth retardation ( J:152332 )

• 20% until 24 weeks of age

homeostasis/metabolism

decreased circulating cholesterol level ( J:152332 )

decreased circulating triglyceride level ( J:152332 )

cellular

decreased fibroblast proliferation ( J:152332 )

• mouse embryonic fibroblasts with low expression of the allele exhibit decreased proliferation compared with wild-type cells

• however, MEFs expressing high levels of the allele exhibit normal proliferation

embryo

decreased embryo size ( J:152332 )

• in 30% of mice at E13.5