Phenotypes Associated with This Genotype

Genotype
MGI:4357965

• Allelic Composition: Kif7^tm1.2Hui/Kif7^tm1.2Hui; Smo^tm1Amc/Smo^tm1Amc
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:152259 )

• at E9.0, the prospective spinal cord contains Oligo2+ progenitors and scattered Nkx2-2+ progenitor cells compared to in wild-type mice

abnormal neural tube morphology ( J:152259 )

• expression of ventral neural tube patterning markers is altered compared to in wild-type mice

exencephaly ( J:152259 )

absent neuronal precursor cells ( J:152259 )

• at E9.0, Shh+ and Foxa2+ progenitor cells are absent

embryo

embryo phenotype ( J:152259 )

N • at E9.0, embryos are larger than Smo^tm1Amc homozygotes

abnormal neural tube morphology ( J:152259 )

• expression of ventral neural tube patterning markers is altered compared to in wild-type mice

cellular

abnormal neuron differentiation ( J:152259 )

• at E9.0, the prospective spinal cord contains Oligo2+ progenitors and scattered Nkx2-2+ progenitor cells compared to in wild-type mice