About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4356292
Allelic
Composition		 Il2rgtm1Wjl/Il2rgtm1Wjl
Tg(CD2-Ccdc86)1Hfuj/?
Genetic
Background		 B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (88 available); any Il2rg mutation (133 available)
Tg(CD2-Ccdc86)1Hfuj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:151722 )
N
• the presence of the transgene prevents the splenomegaly associated with Il2rgtm1Wjl homozygotes due to decreased lymphocyte numbers and size
decreased CD4-positive, alpha-beta T cell number ( J:151722 )
• CD4 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
decreased CD8-positive, alpha-beta T cell number ( J:151722 )
• CD8 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
decreased regulatory T cell number ( J:151722 )
• the transgene fails to rescue the decreased numbers of FoxP3+ regulatory T cells associated with Il2rgtm1Wjl homozygotes
decreased splenocyte number ( J:151722 )
• splenocyte number is decreased compared to wild-type and to Il2rgtm1Wjl homozygotes

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:151722 )
• CD4 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
decreased CD8-positive, alpha-beta T cell number ( J:151722 )
• CD8 T cell numbers are decreased compared to wild-type and to Il2rgtm1Wjl homozygotes
decreased regulatory T cell number ( J:151722 )
• the transgene fails to rescue the decreased numbers of FoxP3+ regulatory T cells associated with Il2rgtm1Wjl homozygotes
decreased splenocyte number ( J:151722 )
• splenocyte number is decreased compared to wild-type and to Il2rgtm1Wjl homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory