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Phenotypes Associated with This Genotype
Genotype
MGI:4356290
Allelic
Composition
Il2ratm1Dw/Il2ratm1Dw
Tg(CD2-Ccdc86)1Hfuj/?
Genetic
Background
B6.Cg-Il2ratm1Dw Tg(CD2-Ccdc86)1Hfuj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2ratm1Dw mutation (3 available); any Il2ra mutation (38 available)
Tg(CD2-Ccdc86)1Hfuj mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• the presence of the transgene prevents the splenomegaly, the large number of T cells, and high circulating levels of IL-17 normally found in Il2ratm1Dw homozygotes
• high expression of CD44 and CD69 suggests the transgene does not prevent the aberrant activation of peripheral T cells

hematopoietic system
• high expression of CD44 and CD69 suggests the transgene does not prevent the aberrant activation of peripheral T cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/31/2026
MGI 6.24
The Jackson Laboratory