Phenotypes Associated with This Genotype

Genotype
MGI:4356148

• Allelic Composition: Sox17^tm1Jaw/Sox17^tm1Sjm; Tg(Foxa3-cre)1Khk/0
• Genetic Background: involves: 129 * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal bile duct development ( J:151981 )

• at E9.5, Ipfl (Pdx1)+ cells are found throughout the liver bud unlike in control mice

• at E10.5, the biliary/gall bladder primordium is absent unlike in control mice

• however, cell proliferation and apoptosis rates are normal

liver/biliary system

abnormal bile duct development ( J:151981 )

• at E9.5, Ipfl (Pdx1)+ cells are found throughout the liver bud unlike in control mice

• at E10.5, the biliary/gall bladder primordium is absent unlike in control mice

• however, cell proliferation and apoptosis rates are normal