Phenotypes Associated with This Genotype

Genotype
MGI:4356105

• Allelic Composition: Pcdha^tm5.1Tyag/Pcdha^tm5.1Tyag
• Genetic Background: B6.Cg-Pcdha^tm5.1Tyag

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus morphology ( J:151979 )

• serotonergic fibers are increased in the lacunosum-moleculare (170%) and decreased in the dentate gyrus (41%) compared to in wild-type mice

abnormal dentate gyrus morphology ( J:151979 )

• serotonergic fibers are decreased 41% in the dentate gyrus compared to in wild-type mice

abnormal serotonergic neuron morphology ( J:151979 )

• mice exhibit abnormal serotonergic fibers in the cerebral cortex, hippocampus, basal ganglia, and thalamus compared to in wild-type mice

growth/size/body

decreased body weight ( J:151979 )

• between 12 and 96 weeks

behavior/neurological

increased grooming behavior ( J:151979 )

• resulting in lesions

homeostasis/metabolism

abnormal serotonin level ( J:151979 )

• at 10 weeks, the level of serotonin is higher in the hippocampus compared to in wild-type mice

integument

skin lesions ( J:151979 )

• by 36 weeks, mice develop lesions on their head, neck, and snout unlike in wild-type mice

• at 96 weeks, 50% of mice exhibit lesions on their bodies unlike wild-type mice