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Phenotypes Associated with This Genotype
Genotype
MGI:4356085
Allelic
Composition		 Etv6tm1(RUNX1)Haho/Etv6+
Runx1tm3Spe/Runx1tm3Spe
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6tm1(RUNX1)Haho mutation (1 available); any Etv6 mutation (144 available)
Runx1tm3Spe mutation (0 available); any Runx1 mutation (34 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:151639 )
• all mice die within 8 days of treatment with pIpC unlike control mice

hematopoietic system
anemia ( J:151639 )
• severe following pIpC treatment
decreased hematopoietic stem cell number ( J:151639 )
• following pIpC treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory